It’s NFC West time on Thursday Night Football as the Arizona Cardinals host the Seattle Seahawks at State Farm Stadium. Both teams enter Week 4 with 2-1 records, setting the stage for a pivotal early-season division showdown. The Seahawks have dominated this matchup recently, winning the last seven meetings, but the Cardinals are eager to flip the script in front of their home crowd.
NFL Week 4 Seahawks at Cardinals Betting Tips
Friday 26th September, 10.15am (AEST)
Cardinals
The Cardinals are coming off a narrow 16–15 loss to the San Francisco 49ers, a game they nearly stole with a late-game surge. Quarterback Kyler Murray has shown flashes of brilliance, but consistency remains a question mark. Arizona's defense has been solid, but they haven't faced an offense as potent as Seattle's in 2025. This game will test whether the Cardinals can elevate their play against a division rival.
Roster-wise, Arizona is relatively healthy, but they'll need to execute flawlessly to keep pace with the Seahawks. With a home crowd behind them, the Cardinals have the opportunity to make a statement and challenge Seattle's dominance in the division.
Seahawks
The Seahawks have bounced back from a season-opening loss with two consecutive victories, including a dominant 44–13 win over the New Orleans Saints in Week 3. Quarterback Sam Darnold has been efficient, and the defense has been stifling, allowing just 16 points over the past two games. Seattle's ability to control the game on both sides of the ball makes them a formidable opponent.
In terms of roster moves, Seattle has been active ahead of their Week 4 matchup against the Arizona Cardinals. Wide receiver Cody White has been promoted from the practice squad to the active roster for the fifth time this season, replacing safety Jerrick Reed, who was waived. Additionally, the Seahawks finalized the signing of running back Khalil Herbert to the practice squad. These moves indicate a commitment to depth and adaptability as they prepare for the Thursday night clash. Seattle's momentum and roster flexibility give them an edge heading into this divisional matchup.
Prediction
While the Cardinals have the home-field advantage, the Seahawks' recent form and historical dominance in this matchup can't be ignored. Seattle's defense is playing at a high level, and their offense has found a rhythm. Arizona will keep it close, but in the end, the Seahawks' experience and depth will prevail. Expect a competitive game, but Seattle is poised to extend their winning streak against the Cardinals.
Seattle H2H
$1.87 (1.5 Units)
Player Prop
Kyler Murray has struggled against NFC West opponents, with a 2-8 record against Seattle. The Seahawks' defense has been formidable, especially their secondary, which ranks among the best in the league when healthy. With the Cardinals' offensive line facing pressure and Murray's inconsistency, the under on his passing yards is a solid bet
Kyler Murray Under 209.5 Pass Yards
$1.88
