The NFL regular season is back, and Monday's slate is loaded with division battles, primetime fireworks, and a handful of early tests that could set the tone for the year ahead. With rivalries renewed and playoff hopefuls looking to make an opening statement, NFL Week 1 offers plenty of intrigue for bettors.
We have previews for the key matchups of the day as well as betting tips for every game. Remember to check back at our NFL Tips page for regular updates on all marquee NFL fixtures this season!
2025-26 NFL Week 1 Monday Betting Tips
Las Vegas Raiders at New England Patriots
Monday, September 8th 2025, 3.00am AEST
The Raiders open their campaign with a daunting trip to Foxborough, a place where their history has been nothing short of cruel. Vegas has struggled to build momentum in season openers in recent years, and this matchup pits them against a defense that loves to feast on mistakes. Much will rest on whether the Raiders can establish the run and protect their quarterback against a disciplined Patriots front. If they fall behind early, it could be a long night.
New England, on the other hand, begins the Mike Vrabel era at home and will be looking to make a statement. The Patriots’ offense has been under the microscope throughout the offseason, with fans eager to see if the young quarterback can take a step forward under Vrabel’s no-nonsense system. The defense remains the bedrock of this team, and opening in Foxborough gives them a chance to set a defensive tone early in the season.
Given the historical dominance the Patriots have enjoyed in this fixture and the questions that still surround the Raiders, the home side looks like the safer play. Expect New England to control the tempo, win the turnover battle, and grind out a seven to ten point victory.
Detroit Lions at Green Bay Packers
Monday, September 8th, 6.25am AEST
The Lions enter 2025 with genuine Super Bowl aspirations after back-to-back years of playoff contention. Dan Campbell’s squad has built its identity on physicality and relentless energy, and this opener at Lambeau is the perfect opportunity to remind the NFC North who the team to beat really is. Jared Goff has the weapons to stretch the field, while Aidan Hutchinson anchors a defense that continues to trend upward. The Lions are past the point of moral victories. they want to walk into Green Bay and assert dominance.
The Packers, meanwhile, are never an easy out at home, and this opener has all the ingredients of a statement game for Jordan Love. Coming off a season in which Green Bay’s young core flashed real promise, the Packers will be eager to prove they can punch back against the division favorite. Their defense, potentially bolstered by Micah Parsons if he suits up, has the speed to test Detroit’s offensive line, and Lambeau under the lights has always carried a certain magic.
This has the makings of a shootout, and while Green Bay should keep it close, Detroit’s cohesion and confidence stand out. The Lions’ balanced attack gives them just enough to escape with a hard-fought road win, likely by a field goal in the final minutes.
Baltimore Ravens at Buffalo Bills
Monday, September 8th 10.20am AEST
Few Week 1 matchups carry as much weight as this Sunday night clash between two AFC powerhouses. Baltimore comes in with revenge on its mind after falling short against Buffalo in the playoffs last season, and Lamar Jackson will be desperate to start the year with a statement. The Ravens’ ground game looks as dangerous as ever, and their defense is built to make quarterbacks uncomfortable. If they can generate pressure early, they’ll believe they can flip the script from last January.
The Bills open their season in prime time with plenty of expectation. This will be Buffalo’s farewell tour at Highmark Stadium before their new home opens, and you can expect the energy in the stands to match the stakes. Josh Allen still leads one of the league’s most explosive offenses, and even with changes on defense, most notably the absence of Micah Hyde, the Bills remain a formidable opponent, especially in front of their home fans.
This feels like a playoff game dropped right into Week 1. The Ravens have every chance to spoil the party, but Buffalo’s ability to turn primetime home games into emotional, chaotic victories can’t be ignored. Expect fireworks, but the Bills hold on late for a narrow four-point win.
Other NFL Week 1 Monday Tips
Miami Dolphins at Indianapolis Colts - Dolphins + 1.5 ($1.88 at Dabble)
Pittsburgh Steelers at New York Jets - Under 37.5 ($1.89 at Dabble)
Tampa Bay Buccaneers at Atlanta Falcons - Falcons +1.5 ($1.90 at Dabble)
Cincinnati Bengals at Cleveland Browns - Bengals -5.5 ($1.88 at Dabble)
Arizona Cardinals at New Orleans Saints - Over 42.5 ($1.88 at Dabble)
New York Giants at Washington Commanders - Giants +6.5 ($1.89 at Dabble)
Carolina Panthers at Jacksonville Jaguars - Jaguars -3.5 ($1.89 at Dabble)
Tennessee Titans at Denver Broncos - Titans +8.5 ($1.90 at Dabble)
San Francisco 49ers at Seattle Seahawks - Over 43.5 ($1.88 at Dabble)
Houston Texans at Los Angeles Rams - Rams -3 ($1.88 at Dabble)
